Breast Cancer Genomics

(BRCA1, BRCA2, ERBB2, ESR1, PALB2, РІКЗСА)

An estimated 19 million people worldwide carry mutations in BRCA1 and BRAC2 genes

The BRCA-1 and BRCA-2 genetic test checks for changes in two genes that can raise the risk of breast and ovarian cancer. Here’s what you need to know:

  1. BRCA-1 and BRCA-2 are special genes in our bodies that usually help stop cancer from
  2. But if these genes have harmful changes, it can make cancer more likely, especially breast and ovarian cancer in women, and breast cancer in
  3. This test looks at DNA and proteins in your blood to find these harmful
  4. Around 5-10% of breast cancer and 10-15% of ovarian cancer cases in white women in the US are linked to these gene
  5. Having these gene changes doesn’t mean you’ll definitely get cancer, and not everyone with cancer has these gene
  6. But if you have these changes, your risk of breast cancer can go up to five times higher, and your risk of ovarian cancer also goes up a
  7. Most of what we know about these genes comes from studying big families with lots of cancer cases, so it might not apply to

The BRCA-1 and BRCA-2 genetic test is not usually recommended for everyone. But Doctors may suggest it for people who:

  1. Got breast cancer when they were 50 or younger-
  2. Got ovarian cancer at any age
  3. Had cancer in both breasts, either personally or in their family- Had male family members with breast
  4. Have a close relative who had breast cancer before they were
  5. Have three or more close relatives with breast cancer at any
  6. Have a close relative with ovarian cancer at any
  7. Have family members with both breast and ovarian cancers, on either their mother’s or father’s
  8. Had breast cancer that tested negative for certain receptors called Oestrogen, Progesterone, and HER2/Neu.
  9. Are of Ashkenazi Jewish descent and have a close relative with breast or ovarian cancer.